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Frontiers | Glutathione Peroxidase 4 as a Therapeutic Target for Anti-Colorectal Cancer Drug-Tolerant Persister Cells
After 2 h of attachment, 75 × 10 5 cells/well in 24-well dishes were incubated with or without SAMe (6 mM), methionine-deficient medium, the protein kinase RNA-like endoplasmic reticulum kinase (PERK) inhibitor GSK2606414 (2 µM), the PPARα inhibitor GW6471 (100 µM), N-acetylcysteine (1 mM) and reduced glutathione (GSH) ester (5 mM) and the NRF2 inhibitor ML385 (10 µM)
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Color:4NF Medium Brown Cool Neutral
Although the molecular determinants stabilizing GPx-1 transcripts have not yet been identified, protein kinase C (PKC)-mediated pathways are essential for adenosine-mediated GPx-1 upregulation, as bisindolylmaleimide-1, a nonspecific PKC-inhibitor, blocked upregulation